Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review.
Identifieur interne : 000556 ( Main/Exploration ); précédent : 000555; suivant : 000557Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review.
Auteurs : E C Reynolds [Australie]Source :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 0275-1879 ]
Descripteurs français
- KwdFr :
- Animaux (MeSH), Association médicamenteuse (MeSH), Caries dentaires (prévention et contrôle), Cariostatiques (composition chimique), Cariostatiques (pharmacocinétique), Cariostatiques (pharmacologie), Cariostatiques (usage thérapeutique), Caséines (pharmacologie), Caséines (usage thérapeutique), Données de séquences moléculaires (MeSH), Fluorures (usage thérapeutique), Fragments peptidiques (MeSH), Humains (MeSH), Peptides (composition chimique), Peptides (usage thérapeutique), Phosphates de calcium (composition chimique), Phosphates de calcium (pharmacocinétique), Phosphates de calcium (usage thérapeutique), Phosphopeptides (pharmacologie), Phosphopeptides (usage thérapeutique), Plaque dentaire (métabolisme), Reminéralisation des dents (méthodes), Régime cariogène (MeSH), Synergie des médicaments (MeSH), Séquence d'acides aminés (MeSH).
- MESH :
- composition chimique : Cariostatiques, Peptides, Phosphates de calcium.
- métabolisme : Plaque dentaire.
- méthodes : Reminéralisation des dents.
- pharmacocinétique : Cariostatiques, Phosphates de calcium.
- pharmacologie : Cariostatiques, Caséines, Phosphopeptides.
- prévention et contrôle : Caries dentaires.
- usage thérapeutique : Cariostatiques, Caséines, Fluorures, Peptides, Phosphates de calcium, Phosphopeptides.
- Animaux, Association médicamenteuse, Données de séquences moléculaires, Fragments peptidiques, Humains, Régime cariogène, Synergie des médicaments, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Animals (MeSH), Calcium Phosphates (chemistry), Calcium Phosphates (pharmacokinetics), Calcium Phosphates (therapeutic use), Cariostatic Agents (chemistry), Cariostatic Agents (pharmacokinetics), Cariostatic Agents (pharmacology), Cariostatic Agents (therapeutic use), Caseins (pharmacology), Caseins (therapeutic use), Dental Caries (prevention & control), Dental Plaque (metabolism), Diet, Cariogenic (MeSH), Drug Combinations (MeSH), Drug Synergism (MeSH), Fluorides (therapeutic use), Humans (MeSH), Molecular Sequence Data (MeSH), Peptide Fragments (MeSH), Peptides (chemistry), Peptides (therapeutic use), Phosphopeptides (pharmacology), Phosphopeptides (therapeutic use), Tooth Remineralization (methods).
- MESH :
- chemical , chemistry : Calcium Phosphates, Cariostatic Agents, Peptides.
- chemical , pharmacokinetics : Calcium Phosphates, Cariostatic Agents.
- chemical , pharmacology : Cariostatic Agents, Caseins, Phosphopeptides.
- chemical , therapeutic use : Calcium Phosphates, Cariostatic Agents, Caseins, Fluorides, Peptides, Phosphopeptides.
- metabolism : Dental Plaque.
- methods : Tooth Remineralization.
- prevention & control : Dental Caries.
- Amino Acid Sequence, Animals, Diet, Cariogenic, Drug Combinations, Drug Synergism, Humans, Molecular Sequence Data, Peptide Fragments.
Abstract
Using laboratory, animal, and human in situ caries models, investigators have shown that casein phosphopeptide amorphous calcium phosphate complexes (CPP-ACP) exhibit an anticariogenic activity. The casein phosphopeptides (CPP) are produced from a tryptic digest of the milk protein casein by aggregation with calcium phosphate and purification by ultrafiltration. The CPP have a remarkable ability to stabilize calcium phosphate in solution and substantially increase the level of calcium phosphate in dental plaque. Through their multiple phosphoseryl residues, the CPP bind to forming clusters of amorphous calcium phosphate (ACP) in metastable solution, preventing their growth to the critical size required for nucleation and precipitation. The proposed mechanism of anticariogenicity for the CPP-ACP is that they localize ACP in dental plaque, which buffers the free calcium and phosphate lon activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel depressing demineralization and enhancing remineralization. The CPP-ACP, unlike fluoride, can be added to sugar-containing foods and therefore have commercial potential as an additive to foods as well as to toothpastes and mouthwashes for the control of dental caries.
DOI: 10.1111/j.1754-4505.1998.tb01353.x
PubMed: 9791302
Affiliations:
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(État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author></analytic><series><title level="j">Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</title><idno type="ISSN">0275-1879</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Animals (MeSH)</term><term>Calcium Phosphates (chemistry)</term><term>Calcium Phosphates (pharmacokinetics)</term><term>Calcium Phosphates (therapeutic use)</term><term>Cariostatic Agents (chemistry)</term><term>Cariostatic Agents (pharmacokinetics)</term><term>Cariostatic Agents (pharmacology)</term><term>Cariostatic Agents (therapeutic use)</term><term>Caseins (pharmacology)</term><term>Caseins (therapeutic use)</term><term>Dental Caries (prevention & control)</term><term>Dental Plaque (metabolism)</term><term>Diet, Cariogenic (MeSH)</term><term>Drug Combinations (MeSH)</term><term>Drug Synergism (MeSH)</term><term>Fluorides (therapeutic use)</term><term>Humans (MeSH)</term><term>Molecular Sequence Data (MeSH)</term><term>Peptide Fragments (MeSH)</term><term>Peptides (chemistry)</term><term>Peptides (therapeutic use)</term><term>Phosphopeptides (pharmacology)</term><term>Phosphopeptides (therapeutic use)</term><term>Tooth Remineralization (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Association médicamenteuse (MeSH)</term><term>Caries dentaires (prévention et contrôle)</term><term>Cariostatiques (composition chimique)</term><term>Cariostatiques (pharmacocinétique)</term><term>Cariostatiques (pharmacologie)</term><term>Cariostatiques (usage thérapeutique)</term><term>Caséines (pharmacologie)</term><term>Caséines (usage thérapeutique)</term><term>Données de séquences moléculaires (MeSH)</term><term>Fluorures (usage thérapeutique)</term><term>Fragments peptidiques (MeSH)</term><term>Humains (MeSH)</term><term>Peptides (composition chimique)</term><term>Peptides (usage thérapeutique)</term><term>Phosphates de calcium (composition chimique)</term><term>Phosphates de calcium (pharmacocinétique)</term><term>Phosphates de calcium (usage thérapeutique)</term><term>Phosphopeptides (pharmacologie)</term><term>Phosphopeptides (usage thérapeutique)</term><term>Plaque dentaire (métabolisme)</term><term>Reminéralisation des dents (méthodes)</term><term>Régime cariogène (MeSH)</term><term>Synergie des médicaments (MeSH)</term><term>Séquence d'acides aminés (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium Phosphates</term><term>Cariostatic Agents</term><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Calcium Phosphates</term><term>Cariostatic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cariostatic Agents</term><term>Caseins</term><term>Phosphopeptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Calcium Phosphates</term><term>Cariostatic Agents</term><term>Caseins</term><term>Fluorides</term><term>Peptides</term><term>Phosphopeptides</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Cariostatiques</term><term>Peptides</term><term>Phosphates de calcium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dental Plaque</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tooth Remineralization</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Plaque dentaire</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Reminéralisation des dents</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Cariostatiques</term><term>Phosphates de calcium</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Cariostatiques</term><term>Caséines</term><term>Phosphopeptides</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Dental Caries</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Caries dentaires</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Cariostatiques</term><term>Caséines</term><term>Fluorures</term><term>Peptides</term><term>Phosphates de calcium</term><term>Phosphopeptides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Diet, Cariogenic</term><term>Drug Combinations</term><term>Drug Synergism</term><term>Humans</term><term>Molecular Sequence Data</term><term>Peptide Fragments</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association médicamenteuse</term><term>Données de séquences moléculaires</term><term>Fragments peptidiques</term><term>Humains</term><term>Régime cariogène</term><term>Synergie des médicaments</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using laboratory, animal, and human in situ caries models, investigators have shown that casein phosphopeptide amorphous calcium phosphate complexes (CPP-ACP) exhibit an anticariogenic activity. The casein phosphopeptides (CPP) are produced from a tryptic digest of the milk protein casein by aggregation with calcium phosphate and purification by ultrafiltration. The CPP have a remarkable ability to stabilize calcium phosphate in solution and substantially increase the level of calcium phosphate in dental plaque. Through their multiple phosphoseryl residues, the CPP bind to forming clusters of amorphous calcium phosphate (ACP) in metastable solution, preventing their growth to the critical size required for nucleation and precipitation. The proposed mechanism of anticariogenicity for the CPP-ACP is that they localize ACP in dental plaque, which buffers the free calcium and phosphate lon activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel depressing demineralization and enhancing remineralization. The CPP-ACP, unlike fluoride, can be added to sugar-containing foods and therefore have commercial potential as an additive to foods as well as to toothpastes and mouthwashes for the control of dental caries.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9791302</PMID><DateCompleted><Year>1998</Year><Month>11</Month><Day>03</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0275-1879</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>1</Issue><PubDate><MedlineDate>1998 Jan-Feb</MedlineDate></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review.</ArticleTitle><Pagination><MedlinePgn>8-16</MedlinePgn></Pagination><Abstract><AbstractText>Using laboratory, animal, and human in situ caries models, investigators have shown that casein phosphopeptide amorphous calcium phosphate complexes (CPP-ACP) exhibit an anticariogenic activity. The casein phosphopeptides (CPP) are produced from a tryptic digest of the milk protein casein by aggregation with calcium phosphate and purification by ultrafiltration. The CPP have a remarkable ability to stabilize calcium phosphate in solution and substantially increase the level of calcium phosphate in dental plaque. Through their multiple phosphoseryl residues, the CPP bind to forming clusters of amorphous calcium phosphate (ACP) in metastable solution, preventing their growth to the critical size required for nucleation and precipitation. The proposed mechanism of anticariogenicity for the CPP-ACP is that they localize ACP in dental plaque, which buffers the free calcium and phosphate lon activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel depressing demineralization and enhancing remineralization. The CPP-ACP, unlike fluoride, can be added to sugar-containing foods and therefore have commercial potential as an additive to foods as well as to toothpastes and mouthwashes for the control of dental caries.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reynolds</LastName><ForeName>E C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>School of Dental Science, University of Melbourne, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Spec Care Dentist</MedlineTA><NlmUniqueID>8103755</NlmUniqueID><ISSNLinking>0275-1879</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002130">Calcium Phosphates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002327">Cariostatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002364">Caseins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010446">Peptide Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010748">Phosphopeptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C519480">amorphous calcium phosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q80VPU408O</RegistryNumber><NameOfSubstance UI="D005459">Fluorides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002130" MajorTopicYN="N">Calcium Phosphates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002327" MajorTopicYN="N">Cariostatic Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002364" MajorTopicYN="N">Caseins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003731" MajorTopicYN="N">Dental Caries</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003773" MajorTopicYN="N">Dental Plaque</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004037" MajorTopicYN="N">Diet, Cariogenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004357" MajorTopicYN="N">Drug Synergism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005459" MajorTopicYN="N">Fluorides</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010446" MajorTopicYN="N">Peptide Fragments</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010748" MajorTopicYN="N">Phosphopeptides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014089" MajorTopicYN="N">Tooth Remineralization</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>61</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>10</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>10</Month><Day>29</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>10</Month><Day>29</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9791302</ArticleId><ArticleId IdType="doi">10.1111/j.1754-4505.1998.tb01353.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Reynolds, E C" sort="Reynolds, E C" uniqKey="Reynolds E" first="E C" last="Reynolds">E C Reynolds</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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